July 2nd, 2006



Депривация сна - вещь опасная. Но, оказывается, не всегда...

The study, published online in PloS Biology, found that a group of sparrows studied in the laboratory dramatically reduced how long they slept during the time they would ordinarily be migrating. But they were nonetheless able to function and perform normally despite their sleep deprivation. During times when the birds were not migrating, however, sleep deprivation appeared to impair their performance - similar to what happens to sleep-deprived humans.

PLoS Biology, July 2004
No Rest for the Weary: Migrating Songbirds Keep Their Wits without Sleep (Synopsis)

Migratory Sleeplessness in the White-Crowned Sparrow (Research article)

т.е. мозг способен нормально функционировать в существенно разных режимах.
Это делает вопрос о роли сна как неизбежного условия развитой ВНД еще более интригующим.


Nature Reviews Molecular Cell Biology, June 2006
Chromatin remodelling: the industrial revolution of DNA around histones

Chromatin remodellers are specialized multi-protein machines that enable access to nucleosomal DNA by altering the structure, composition and positioning of nucleosomes. All remodellers have a catalytic ATPase subunit that is similar to known DNA-translocating motor proteins, suggesting DNA translocation as a unifying aspect of their mechanism. Here, we explore the diversity and specialization of chromatin remodellers, discuss how nucleosome modifications regulate remodeller activity and consider a model for the exposure of nucleosomal DNA that involves the use of directional DNA translocation to pump 'DNA waves' around the nucleosome.

The Cairns Lab is interested in how chromatin structure helps regulate transcription. We purify and characterize large protein complexes that remodel chromosomal structure, and use genetic and genomic methods to understand their functions in living cells. Here, we provide an overview of chromatin regulation followed by a description of current lab projects.